Insulin Resistance
IKK-beta inhibition holds promise as a treatment for insulin resistance
Published in Obesity and Diabetes Week, April 11th, 2005
According to a recent study published in the journal Nature Medicine, "Inflammation may underlie the metabolic disorders of insulin resistance and type 2 diabetes. IkappaB kinase beta (IKK-beta, encoded by Ikbkb) is a central coordinator of inflammatory responses through activation of NF-kappaB."
M.C. Arkan and associates, at the University of California, San Diego, wrote, "To understand the role of IKK-beta in insulin resistance, we used mice lacking this enzyme in hepatocytes (Ikbkb(Deltahep)) or myeloid cells (Ikbkb(Deltamye))."
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