Diabetes Pathogenesis
Polypyrimidine tract binding protein controls insulin production
Published in Obesity and Diabetes Week, April 18th, 2005
According to recent research published in the journal Biochemical and Biophysical Research Communications, "The aim of this study was to further elucidate the role of the polypyrimidine tract binding protein (PTB) in the control of insulin mRNA stability."
R.G. Fred and associates explained, "We observed that the glucose- or interleukin-1beta-induced increase in insulin mRNA was paralleled by an increase in PTB mRNA. To further test the hypothesis that PTB controls insulin gene expression, betaTC-6 cells were treated with a PTB-specific siRNA to...
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