Pancreatic Agenesis
TCF2/vHNF1 is linked to pancreas agenesis
Published in Obesity and Diabetes Week, April 18th, 2005
According to a study from France, "Heterozygous mutations in the human POLI-homeobox TCF2 (vHNF1, HNF1beta) gene are associated with maturity-onset diabetes of the young, type 5, and abnormal urogenital tract development. Recently, pancreas atrophies have been reported in several maturity-onset diabetes of the young type 5 patients, suggesting that TCF2 is required not only for adult pancreas function but also for its normal development. Tcf2-deficient mice die before gastrulation because of defective visceral endoderm formation."
C. Haumaitre and colleagues reported, "To investigate the role of...
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