Diabetes Pathogenesis

Hypoplasia of endocrine and exocrine pancreas in TGF-beta 1 described

Published in Obesity and Diabetes Week, April 25th, 2005

Researchers describe hypoplasia of endocrine and exocrine pancreas in homozygous transgenic TGF-beta 1 in a recent issue of Molecular and Cellular Endocrinology.

"We generated the homozygous transgenic mice with expression of the active form of TGF-beta1 by the glucagon promoter (homozygous NOD-TGF-beta1). The homozygous NOD-TGF-beta1 showed severe diabetes in 84.6%, impaired glucose tolerance, and low-serum insulin levels. The final size of endocrine and whole pancreas decreased, respectively, to 6 and 34%, compared to wild-type mice. The homozygous N₂ backcross to C57BL/6 (B6-TGF-beta1) showed no diabetes, but impaired glucose tolerance and low...

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Source: Obesity and Diabetes Week (2005-04-25)

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