Published in Obesity and Diabetes Week, April 25th, 2005
"We generated the homozygous transgenic mice with expression of the active form of TGF-beta1 by the glucagon promoter (homozygous NOD-TGF-beta1). The homozygous NOD-TGF-beta1 showed severe diabetes in 84.6%, impaired glucose tolerance, and low-serum insulin levels. The final size of endocrine and whole pancreas decreased, respectively, to 6 and 34%, compared to wild-type mice. The homozygous N2 backcross to C57BL/6 (B6-TGF-beta1) showed no diabetes, but impaired glucose tolerance and low...
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