Diabetes Therapy
Thiazolidinediones upregulate fatty acid uptake in adipose tissue
Published in Obesity and Diabetes Week, May 2nd, 2005
According to published research from the United States, "Thiazolidinediones (TZDs) are a new class of insulin-sensitizing drugs. To explore how and in which tissues they improve insulin action, we obtained fat and muscle biopsies from eight patients with type 2 diabetes before and 2 months after treatment with rosiglitazone (n=5) or troglitazone (n=3). TZD treatment was associated with a coordinated upregulation in the expression of genes and synthesis of proteins involved in fatty acid uptake, binding, beta-oxidation and electron transport, and oxidative...
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