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Diabetes Pathogenesis

Data advance knowledge in diabetes pathogenesis research

Published in Obesity and Diabetes Week, May 9th, 2005

Diabetes pathogenesis data are the focus of recent research from Italy and the United States.

Study 1: Researchers have investigated beta-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes.

According to a study from the United States and Italy, "The nature of the progressive beta-cell failure occurring as normal glucose tolerant (NGT) individuals progress to type 2 diabetes (T2DM) is incompletely understood. We measured insulin sensitivity (by a euglycemic insulin clamp) and insulin secretion rate (by deconvolution of plasma C-peptide levels during an oral glucose tolerance test) in 188 subjects [19 lean NGT...

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