Obesity Pathogenesis

Aminotransferase gene polymorphism associated with measures of obesity

Published in Obesity and Diabetes Week, May 9th, 2005

The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects.

According to recent research from Germany, "Increases in glutamine:fructose-6-phosphate aminotransferase (GFAT) protein levels directly activate flux through the hexosamine biosynthetic pathway. This pathway has been involved as a fuel sensor in energy metabolism and development of insulin resistance. We screened the 5'-flanking region of the human GFAT gene for polymorphisms and subsequently genotyped 412 nondiabetic, metabolically characterized Caucasians for the two single-nucleotide...

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Source: Obesity and Diabetes Week (2005-05-09)

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