Metabolic Syndrome
PPAR-delta agonists developed to treat metabolic syndrome
Published in Obesity and Diabetes Week, May 16th, 2005
"Peroxisome proliferator-activated receptors (PPARs) are transcription factors involved in both developmental and metabolic functions. There are activated by fatty acids, fatty acid metabolites, and synthetic compounds marketed for their lipid-lowering and antidiabetic actions. It was clearly established that activation of PPAR-alpha and PPAR-gamma, by fibrates and thiazolidinediones, respectively, impair metabolic disorders," a scientist in France reports.
"The implication of the third member of the PPAR family, PPAR-delta, remained evasive...
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