Published in Obesity and Diabetes Week, May 16th, 2005
Study 1: Recent research from the United States has documented the effects of silencing leukocyte-type lipoxygenase using short interfering RNAs.
"The leukocyte-type 12/15-lipoxygenase (12/15-LO) has been implicated in the pathogenesis of atherosclerosis, hypertension, and diabetes. 12/15-LO and its products are associated with LDL oxidation, cellular growth, migration, adhesion, and inflammatory gene expression in monocytes/macrophages, endothelial cells, and vascular smooth muscle cells (VSMCs).
"Our objective, therefore, was to develop novel...
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