Leptin Studies
Feedback inhibition of leptin receptor/Jak2 signaling investigated
Published in Obesity and Diabetes Week, May 23rd, 2005
According to a study from the United States, "Leptin is an adipocyte-derived hormone that communicates the status of body energy stores to the brain to regulate feeding and energy balance. The inability of elevated leptin levels to adequately suppress feeding in obesity suggests attenuation of leptin action under these conditions; the activation of feedback circuits due to high leptin levels could contribute to this leptin resistance. Using cultured cells exogenously expressing the long form of the leptin receptor (LRb) or...
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