Cardiovascular Disease

Vascular dysfunction of venous bypass conduits mediated by ROS

Published in Obesity and Diabetes Week, May 23rd, 2005

Vascular dysfunction of venous bypass conduits is mediated by reactive oxygen species (ROS) in diabetes.

"Diabetes is associated with increased risk for complications following coronary bypass grafting (CABG) surgery. Augmented superoxide (O₂ radical anion) production plays an important role in diabetic complications by causing vascular dysfunction. The potent vasoconstrictor endothelin-1 (ET-1) is also elevated in diabetes and following CABG; however, the effect of ET-1 on O₂ radical anion generation and/or vascular dysfunction in bypass conduits remain unknown," scientists in the United States and Norway report.

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Source: Obesity and Diabetes Week (2005-05-23)

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