Diabetes Pathogenesis

Insights into amino acids, beta-cell function, and diabetes presented

Published in Obesity and Diabetes Week, May 23rd, 2005

Researchers provide new insights into amino acid metabolism, beta-cell function, and diabetes in a recent issue of Clinical Science.

According to a study from Ireland, "Specific amino acids are now known to acutely and chronically regulate insulin secretion from pancreatic beta cells in vivo and in vitro. Understanding the molecular mechanisms by which amino acids regulate insulin secretion may identify novel targets for future diabetes therapies. Mitochondrial metabolism is crucial for the coupling of amino acid and glucose recognition to the exocytosis of the insulin granules. This is illustrated by in vitro and in vivo observations discussed in the present...

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Source: Obesity and Diabetes Week (2005-05-23)

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