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Lipid Studies

Hepatic fatty acid drainage hypothesis of metabolic syndrome explained

Published in Obesity and Diabetes Week, May 23rd, 2005

Scientists explain the hepatic fatty acid drainage hypothesis of metabolic syndrome in a recent issue of Biochimie.

According to a study from Norway, "Much data indicates that lowering of plasma triglyceride levels by hypolipidemic agents is caused by a shift in the liver metabolism towards activation of peroxisome proliferator activated receptor (PPAR)-alpha-regulated fatty acid catabolism in mitochondria. Feeding rats with lipid lowering agents leads to hypolipidemia, possibly by increased channeling of fatty acids to mitochondrial fatty acid oxidation at the expense of triglyceride synthesis."

"Our hypothesis is that increased hepatic fatty...

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