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Diabetes Therapy

Exenatide improves insulin sensitivity and beta-cell mass

Published in Obesity and Diabetes Week, May 23rd, 2005

Exenatide (Exendin-4) improves insulin sensitivity and beta-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight.

According to published research from the United States, "The effects of the incretin mimetic exenatide (exendin-4) on metabolic parameters, insulin sensitivity, and beta-cell mass were examined in nondiabetic, insulin-resistant obese fa/fa Zucker rats. After 6 weeks of treatment, ad libitum-fed exenatide-treated (EX) and pair-fed vehicle control (PF) rats had comparable food intake, body weight, hemoglobin A1c (HbA1c ), and fasting plasma concentrations of glucose, insulin, and lipids....

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