Diabetes Pathogenesis
Researchers' findings advance diabetes pathogenesis research
Published in Obesity and Diabetes Week, May 30th, 2005
Study 1: Loss of the decrement in intra-islet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes.
According to recent research published in the journal Diabetes, "The intra-islet insulin hypothesis for the signaling of the glucagon secretory response to hypoglycemia states that a decrease in arterial glucose --> a decrease in beta-cell insulin secretion --> a decrease in tonic alpha-cell inhibition by insulin - an increase in alpha-cell glucagon secretion. To test this hypothesis in humans, a...
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