Published in Obesity and Diabetes Week, May 30th, 2005
Study 1: Aldose reductase is required for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells.
According to recent research from the United States, "Activation of protein kinase C (PKC) has been linked to the development of secondary diabetes complications. However, the underlying molecular mechanisms remain unclear. We examined the contribution of aldose reductase, which catalyzes the first, and the rate-limiting, step of the polyol pathway of glucose metabolism,...
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