Diabetes Pathogenesis

Carboxypeptidase E aids processing of amyloid polypeptide in beta cells

Published in Obesity and Diabetes Week, May 30th, 2005

Carboxypeptidase E plays a role in processing of pro-islet amyloid polypeptide in beta cells.

"Islet amyloid polypeptide (IAPP; amylin) is a peptide hormone that is co-secreted with insulin from beta cells. Impaired processing of proIAPP, the IAPP precursor, has been implicated in islet amyloid formation in type 2 diabetes. We previously showed that proIAPP is processed to IAPP by the prohormone convertases PC1/3 and PC2 at its carboxyl (COOH) and amino (NH₂ ) termini, respectively. In this study, we investigated the role of carboxypeptidase E (CPE) in the processing of proIAPP using mice lacking active CPE (Cpe^fat/Cpe^fat) and NIT-2...

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Source: Obesity and Diabetes Week (2005-05-30)

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