Diabetes Pathogenesis

Recent findings in diabetes pathogenesis provide new insights

Published in Obesity and Diabetes Week, June 6th, 2005

Diabetes pathogenesis research advances have been reported from the United States, Germany and Israel.

Study 1: The C allele of PTPN22 is linked to autoimmunity susceptibility.

According to published research from the United States, "The PTPN22 (protein tyrosine phosphatase N22) gene encodes the protein tyrosine phosphatase Lyp. One function of Lyp is downregulation of T-cell signaling through its interaction with the negative regulatory kinase C-terminal Src tyrosine kinase (Csk). A single nucleotide polymorphism in the PTPN22 gene, C1858T, encodes products with different Csk binding affinities."

M.B. Ladner and associates...

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Source: Obesity and Diabetes Week (2005-06-06)

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