Diabetes Therapy

Researchers detail new studies and findings in the area of diabetes therapy

Published in Obesity and Diabetes Week, June 6th, 2005

Diabetes therapy data are the focus of recent research from Japan, Korea and China.

Study 1: Metabolites of docosahexaenoic acid are potent PPAR-gamma agonists and antidiabetic agents.

"We found that putative metabolites of docosahexaenoic acid (DHA) are strong PPAR-gamma activators and potential antidiabetic agents. We designed DHA derivatives based on the crystal structure of PPAR-gamma, synthesized them and evaluated their activities in vitro and in vivo. The efficacy of 5E-4-hydroxy-DHA as a PPAR-gamma activator was about fourfold stronger than that of pioglitazone," investigators in Japan report.

"Furthermore, the 4-keto...

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Source: Obesity and Diabetes Week (2005-06-06)

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