Published in Obesity and Diabetes Week, June 6th, 2005
Study 1: Metabolites of docosahexaenoic acid are potent PPAR-gamma agonists and antidiabetic agents.
"We found that putative metabolites of docosahexaenoic acid (DHA) are strong PPAR-gamma activators and potential antidiabetic agents. We designed DHA derivatives based on the crystal structure of PPAR-gamma, synthesized them and evaluated their activities in vitro and in vivo. The efficacy of 5E-4-hydroxy-DHA as a PPAR-gamma activator was about fourfold stronger than that of pioglitazone," investigators in Japan report.
"Furthermore, the 4-keto...
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