Diabetes Therapy

Regulatory T cells expressing Foxp3 control diabetogenic T cells

Published in Obesity and Diabetes Week, June 6th, 2005

Regulatory CD8+CD25+ T cells expressing Foxp3 provide control of diabetogenic T cells.

According to study from Denmark, "to understand the ability of regulatory T cells to control diabetes development in clinically relevant situations, we established a new model of accelerated diabetes in young DP-BB rats by transferring purified T cells from DR-BB rats made acutely diabetic. Transfer of 3, 5, 10, or 23 million pure in vitro activated T cells accelerated diabetes onset in >90% of the recipients, with the degree of acceleration being dosage dependent. Cotransfer of unfractionated leukocytes from healthy donors prevented diabetes."

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Source: Obesity and Diabetes Week (2005-06-06)

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