Published in Obesity and Diabetes Week, June 6th, 2005
According to a study from Japan, "Mutations in the hepatocyte nuclear factor (HNF) 4 alpha gene cause a form of maturity-onset diabetes of the young (MODY1), which is a monogenic form of type 2 diabetes characterized by impaired insulin secretion by pancreatic beta cells. HNF4-alpha is a transcription factor expressed in the liver, kidney, intestine, and pancreatic islet. Multiple splice variants of the HNF4-alpha gene have been identified and an isoform of HNF4-alpha 8, an N-terminal splice variant, is expressed in pancreatic beta-cells."
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Obesity and Diabetes Week
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.