Diabetes Pathogenesis

New findings in diabetes pathogenesis described

Published in Obesity and Diabetes Week, June 13th, 2005

Data on diabetes pathogenesis are outlined in reports from Sweden, Australia and the United States.

Study 1: The R6/2 transgenic mouse model of Huntington disease develops diabetes due to deficient beta-cell mass and exocytosis.

According to a study from Sweden, "Diabetes frequently develops in Huntington disease (HD) patients and in transgenic mouse models of HD such as the R6/2 mouse. The underlying mechanisms have not been clarified. Elucidating the pathogenesis of diabetes in HD would improve our understanding of the molecular mechanisms involved in HD neuropathology. With this aim, we examined our colony of R6/2 mice with respect to glucose...

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Source: Obesity and Diabetes Week (2005-06-13)

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