Diabetes Therapy
MafA is a novel therapeutic target for diabetes
Published in Obesity and Diabetes Week, June 27th, 2005
According to researchers in Japan, "MafA, a recently isolated pancreatic beta-cell-specific transcription factor, is a potent activator of insulin gene transcription. In this study, we show that MafA overexpression, together with PDX-1 (pancreatic and duodenal homeobox factor-1) and NeuroD, markedly increases insulin gene expression in the liver."
H. Kaneto and associates at Osaka University explained, "Consequently, substantial amounts of insulin protein were induced by such combination. Furthermore, in streptozotocin-induced...
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