Diabetes Genomics and Genetics

Candidate genes in the type 2 diabetes modifier locus identified

Published in Obesity and Diabetes Week, July 11th, 2005

Researchers have identified candidate genes in the type 2 diabetes modifier locus using expression QTL.

According to a study from Japan, "To identify new genetic determinants relevant to type 2 diabetes (T2D), diabetic F2 progeny were generated by intercrossing F1 mice obtained from a cross of BKS.Cg-Lepr^db+/+m and DBA/2, and T2D-related phenotypes were measured. In the F2 population, increased susceptibility to diabetes and obesity was observed. We also detected the major quantitative trait loci (QTL) modifying the severity of diabetes on chromosome 9, where peaks of logarithm of odds (LOD) overlapped for three traits."

"To identify...

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Source: Obesity and Diabetes Week (2005-07-11)

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