Diabetes Pathogenesis
Studies advance knowledge in diabetes pathogenesis research
Published in Obesity and Diabetes Week, July 25th, 2005
Study 1: Scientists have identified alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics.
According to a study from the United States, "Diabetic cardiomyopathy is the result of maladaptive changes in energy homeostasis. However, the biochemical mechanisms underlying dysfunctional lipid metabolism in diabetic myocardium are incompletely understood. Herein, we exploit shotgun lipidomics to demonstrate a four-fold increase in acylcarnitines in diabetic myocardium, which was reversible upon insulin...
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