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Diabetes Therapy

Crystal structure of 11 beta-hydroxysteroid dehydrogenase 1 reported

Published in Obesity and Diabetes Week, July 25th, 2005

Researchers have determined the crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1, an important therapeutic target for diabetes.

According to recent research from the United States, "11-Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the conversion of 11-dehydrocorticosterone to its active form corticosterone in rodents (or cortisone to cortisol in humans). The reductive reaction of the 11-keto to 11-hydroxyl is the pivotal switch in the activation of glucocorticoids. An excess of active glucocorticoids has been shown to play a key role in metabolic disorders such as diabetes and obesity. Therefore, 11beta-HSD1 represents an important...

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