Published in Obesity and Diabetes Week, August 1st, 2005
"Activated innate immunity is thought to be involved in the pathogenesis of metabolic syndrome and type 2 diabetes. Interleukin-18 (IL-18) is a pleiotropic proinflammatory cytokine with important regulatory functions in the innate immune response. We sought to determine whether an elevated IL-18 concentration was a risk predictor for metabolic syndrome in a community population independent of obesity and hyperinsulinemia. A representative general population, aged 27 to 77 years, without clinical diabetes was studied for clinical and biochemical risk...
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