Obesity and Diabetes

Fenofibrate prevents rosiglitazone-induced body weight gain

Published in Obesity and Diabetes Week, August 8th, 2005

Fenofibrate prevents rosiglitazone-induced body weight gain in ob/ob mice.

According to a study from France, "Fibrates and thiazolidinediones are commonly used for the treatment of dyslipidemia and type 2 diabetes, respectively. The aim of this study was to investigate the effects on body weight as well as on glucose and lipid homeostasis of ligands for PPAR-alpha and PPAR-gamma, fenofibrate, and rosiglitazone, alone or in association."

"Ob/ob mice were divided into four groups: control, and mice daily injected (intraperitoneally), either with 10 mg/kg rosiglitazone, 100 mg/kg fenofibrate, or both molecules," said Maria-Carmen Carmona at Centre...

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Source: Obesity and Diabetes Week (2005-08-08)

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