Diabetes Complications
Polyol pathway inhibition extends peritoneal dialysis longevity
Published in Obesity and Diabetes Week, August 15th, 2005
According to a study from The Netherlands, "peritoneal dialysis with glucose- and lactate-containing dialysis solutions stimulates peritoneal angiogenesis and fibrosis. These serious side effects can also be induced by chronic peritoneal exposure to dialysis solutions in nonuremic rats."
"The high glucose concentrations of the dialysis solutions may saturate physiological glucose metabolism pathways and stimulate the polyol pathway that has been described to damage nerves and vessels in diabetes mellitus," noted R. van Westrhenen and colleagues, University of Amsterdam.
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