Insulin Resistance
PPAR-gamma-activating angiotensin receptor blockers induce adiponectin
Published in Obesity and Diabetes Week, August 22nd, 2005
"The adipose-specific protein adiponectin has been recently discovered to improve insulin sensitivity. Angiotensin type-1 receptor (AT1R) blockers (ARBs) reduce the incidence of type 2 diabetes mellitus by mostly unknown molecular mechanisms. To identify new antidiabetic mechanisms of ARBs, we studied the regulation of adiponectin by angiotensin II (Ang II) and different ARBs in murine 3T3-L1 adipocytes and obese Zucker rats," researchers in Germany report.
"Adiponectin protein expression was markedly stimulated by Ang II (5 nmol/L), which was inhibited by blockade of the...
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