Obesity Pathogenesis
Liver X receptors regulate balance between fat storage and oxidation
Published in Obesity and Diabetes Week, September 5th, 2005
"Despite the well-established role of liver X receptors (LXRs) in regulating cholesterol homeostasis, their contribution to lipid homeostasis remains unclear. Here we show that LXR null mice are defective in hepatic lipid metabolism and are resistant to obesity when challenged with a diet containing both high fat and cholesterol," scientists in the United States report.
"This phenotype is dependent on the presence of dietary cholesterol and is accompanied by the aberrant production of thyroid hormone in liver," said Nada Y. Kalaany and colleagues at the University of Texas...
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