Diabetes Pathogenesis
Leptin receptor signals play role in regulation of glucose homeostasis
Published in Obesity and Diabetes Week, September 12th, 2005
"Leptin activates the long form of the leptin receptor (LRb) to control feeding and neuroendocrine function and thus regulate adiposity. While adiposity influences insulin sensitivity, leptin also regulates glucose homeostasis independently of energy balance. Disruption of the LRb/STAT3 signal in s/s mice results in hyperphagia, neuroendocrine dysfunction, and obesity similar to LRb null db/db mice," scientists in the United States report.
"Insulin resistance and glucose intolerance are improved in s/s compared to db/db animals, however,...
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