Published in Obesity and Diabetes Week, September 12th, 2005
"Phosphatidylinositol (PI) 4,5-bisphosphate (PIP2 ) plays a pivotal role in insulin-stimulated glucose transport as an important precursor to PI 3,4,5-trisphosphate (PIP3 ) and a key regulator of actin polymerization. Since endothelin (ET)-1 impairs insulin sensitivity and PIP(2) is a target of ET-1-induced signaling, we tested whether a change in insulin-stimulated PIP3 generation and signaling, PIP2 -regulated actin polymerization, or a combination of both accounted for ET-1-induced insulin resistance,"...
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