Diabetes Therapy

Phosphatidylinositol 4,5-biphosphate reverses insulin resistance

Published in Obesity and Diabetes Week, September 12th, 2005

Phosphatidylinositol 4,5-biphosphate reverses endothelin-1-induced insulin resistance via an actin-dependent mechanism.

"Phosphatidylinositol (PI) 4,5-bisphosphate (PIP₂ ) plays a pivotal role in insulin-stimulated glucose transport as an important precursor to PI 3,4,5-trisphosphate (PIP₃ ) and a key regulator of actin polymerization. Since endothelin (ET)-1 impairs insulin sensitivity and PIP(2) is a target of ET-1-induced signaling, we tested whether a change in insulin-stimulated PIP₃ generation and signaling, PIP₂ -regulated actin polymerization, or a combination of both accounted for ET-1-induced insulin resistance,"...

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Source: Obesity and Diabetes Week (2005-09-12)

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