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Drug Development

Company announces phase II trial programs for internally developed compounds

Published in Obesity and Diabetes Week, September 12th, 2005

Exelixis, Inc., (EXEL) announced plans for phase II programs for its three most advanced internally generated development compounds, XL999, XL647, and XL784.

XL999 and XL647 are anticancer compounds, currently in late phase I trials, and the company intends to begin a phase II program for each of these compounds before the end of the year. XL784 has completed a single-dose, phase I trial as well as additional toxicology and formulation development in preparation for a phase II program to test its utility in diabetic nephropathy.

Based on the specific targets of each compound, preclinical data, and insights gained during the phase I trials, the...

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