Insulin Resistance

FOXC2 overexpression prevents diet-induced insulin resistance

Published in Obesity and Diabetes Week, September 12th, 2005

Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance.

"Insulin resistance plays a major role in the development of type 2 diabetes and may be causally associated with increased intracellular fat content. Transgenic mice with adipocyte-specific overexpression of FOXC2 (forkhead transcription factor) have been generated and shown to be protected against diet-induced obesity and glucose intolerance," scientists in the United States report.

"To understand the underlying mechanism, we examined the effects of chronic high-fat feeding on tissue-specific insulin action and glucose...

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Source: Obesity and Diabetes Week (2005-09-12)

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