Obesity Pathogenesis

Changes in orexin-A and neuropeptide Y in hypothalamus examined

Published in Obesity and Diabetes Week, September 19th, 2005

Researchers have examined the changes in orexin-A and neuropeptide Y expression in the hypothalamus of obese and lean Zucker diabetic fatty rats.

According to a study from South Korea, "This study was carried out to investigate the changes of orexin-A (OXA) and neuropeptide Y (NPY) expression in the hypothalamus of the obese and lean Zucker Diabetic Fatty (ZDF) rats which have a missense mutation in the leptin receptor gene. The mean body weights (MBW) between the obese and lean ZDF rats were significantly different at 28 and 70 postnatal days. However, at 14 postnatal day, there was no significant difference in the MBW between the obese and lean ZDF rats in both male...

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Source: Obesity and Diabetes Week (2005-09-19)

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