Atherosclerosis

Apolipoprotein E secretion by macrophages in type 2 diabetes evaluated

Published in Obesity and Diabetes Week, September 19th, 2005

Researchers discuss the roles of HDL and apolipoprotein A-I in apolipoprotein E secretion by macrophages in type 2 diabetic patients in a recent issue of Diabetes Research and Clinical Practice.

"It has been shown that apolipoprotein A-I (ApoA-I) stimulates the secretion of apolipoprotein E (ApoE) from human macrophages. ApoA-I is a major protein constituent of HDL which because of its role in reverse cholesterol transport, has been implicated in the prevention of atherosclerosis. We herein investigated the ability of monocyte-derived macrophages (MDMs) in 42 patients with type 2 diabetes to secrete ApoE; these patients commonly have low plasma HDL and ApoA-I...

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Source: Obesity and Diabetes Week (2005-09-19)

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