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Body Composition

Proopiomelanocortin gene polymorphisms linked to body fat distribution

Published in Obesity and Diabetes Week, October 3rd, 2005

Researchers have found an association between common polymorphisms of the proopiomelanocortin gene and body fat distribution.

According to recent research from England, "Rare mutations in the proopiomelanocortin (POMC) gene cause severe early-onset childhood obesity. However, it is unknown whether common variants in POMC are responsible for variation in body weight or fat distribution within the commonly observed range in the population. We tested for association between three polymorphisms spanning the POW gene and obesity phenotypes in 1,428 members of 248 families."

"There was significant association between genotypes at the C8246T (p<0.0001)...

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