Diabetes Genomics & Genetics
Non-HLA genes are associated with type 1 diabetes autoimmunity
Published in Obesity and Diabetes Week, October 3rd, 2005
"Approximately 50% of the genetic risk for type 1 diabetes is attributable to the IIIA region. We evaluated associations between candidate genes outside the HLA region-INS, cytotoxic T-lymphocyte-associated antigen (CTLA)-4, interleukin (IL)-4, IL-4R, and IL-13 and islet autoimmunity among children participating in the Diabetes Autoimmunity Study in the Young (DAISY). Children with persistent islet autoantibody positivity (n=102, 38 of whom have already developed diabetes) and control subjects (n=198) were genotyped for single nucleotide polymorphisms (SNPs) in the candidate genes," investigators in the...
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