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Obesity Pathogenesis

Suppressed skeletal muscle thermogenesis plays role in weight change

Published in Obesity and Diabetes Week, October 3rd, 2005

Suppressed skeletal muscle thermogenesis plays a role in pathways from weight fluctuations to the insulin resistance syndrome.

According to a study from Switzerland, "An impressive body of epidemiological evidence suggests that a history of large perturbations in body weight earlier in life, independently of excess weight, is a risk factor for later development of insulin-related complications, namely central obesity, type 2 diabetes, and cardiovascular disease."

"Such an increased risk has been reported in men and women who in young adulthood experienced weight fluctuations that involved weight recovery after weight loss caused by disease, famine or...

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