Published in Obesity and Diabetes Week, October 3rd, 2005
"We identified a locus on chromosome 6q16.3-q24.2 associated with childhood obesity that includes 2.4 Mb common to eight genome scans for type 2 diabetes (T2D) or obesity. Analysis of the gene ENPP1 (also called PC-1), a candidate for insulin resistance, in 6,147 subjects showed association between a three-allele risk haplotype (K121Q, IVS20delT-11 and A->G+1044TGA; QdelTG) and childhood obesity [odds ratio (OR)=1.69, p=0.0006], morbid or moderate obesity in adults (OR=1.50, p=0.006 or OR=1.37, p=0.02, respectively) and T2D (OR=1.56,...
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