Obesity Risk Factors

Variants of ENPP1 are associated with childhood and adult obesity

Published in Obesity and Diabetes Week, October 3rd, 2005

Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.

"We identified a locus on chromosome 6q16.3-q24.2 associated with childhood obesity that includes 2.4 Mb common to eight genome scans for type 2 diabetes (T2D) or obesity. Analysis of the gene ENPP1 (also called PC-1), a candidate for insulin resistance, in 6,147 subjects showed association between a three-allele risk haplotype (K121Q, IVS20delT-11 and A->G+1044TGA; QdelTG) and childhood obesity [odds ratio (OR)=1.69, p=0.0006], morbid or moderate obesity in adults (OR=1.50, p=0.006 or OR=1.37, p=0.02, respectively) and T2D (OR=1.56,...

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Source: Obesity and Diabetes Week (2005-10-03)

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