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Islet Transplantation

Donor islet cells participate in vessel formation in pancreatic islets

Published in Obesity and Diabetes Week, October 3rd, 2005

Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts.

According to a study from Sweden, "Pancreatic islet transplantation has emerged as a therapy for type 1 diabetes and is today performed using both freshly isolated and cultured islets. Islet blood vessels are disrupted during islet isolation; therefore, proper revascularization of the transplanted islets is of great importance for islet graft function and survival. We have studied intra-islet endothelial cells after islet isolation, during islet culture, and following islet transplantation."

"By isolating islets from the transgenic Tie2-GFP...

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