Islet Transplantation
Islet hormones and N-nitrosomorpholine have carcinogenic effects
Published in Obesity and Diabetes Week, October 3rd, 2005
According to recent research published in the journal Cancer Research, "In contrast to high local insulin levels obtained after low-number transplantation (n=350) of islets of Langerhans into the livers of diabetic rats, low insulin levels after high-number transplantation (n=1,000) do not suffice to induce hepatocarcinogenesis. Herein, we investigated the possible cocarcinogenic potential of high and, in particular, low insulin levels, combining this in vivo model with a chemical model of...
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