Obesity & Diabetes Week
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Insulin Resistance
Caenorhabditis elegans model of insulin resistance developed
October 17th, 2005
Researchers have developed a Caenorhabditis elegans model of insulin resistance. According to a study from the United States, "O-linked N-acetylglucosamine (O-GlcNAc) is an evolutionarily conserved modification of nuclear pore proteins, signaling kinases, and transcription factors. The O-GlcNAc transferase (OGT) catalyzing O-GlcNAc addition is essential in mammals and mediates the last step in a nutrient-sensing 'hexosamine-signaling pathway.' This pathway may be deregulated in diabetes and neurodegenerative disease." "To examine the function of O-GlcNAc in a genetically amenable organism, we describe a putative null allele of OGT in...
Source: Obesity & Diabetes Week (2005-10-17)
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