Liver Disease

A high fat diet alters hepatic immune system in mice

Published in Obesity and Diabetes Week, October 24th, 2005

Mice that were fed diets high in fat and sugar developed immune system abnormalities in their livers, including reduced numbers of natural killer T (NKT) cells.

These diet-related changes may contribute to obesity-related liver disease, according to a new study. The study is published in the October 2005 issue of Hepatology, the official journal of the American Association for the Study of Liver Diseases (AASLD).

NKT cells originate in the thymus but accumulate in the liver where they regulate the production of cytokines (cell proteins). A previous study of leptin-deficient obese mice noted depleted levels of NKT cells. However, since obese...

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Source: Obesity and Diabetes Week (2005-10-24)

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