Vascular Disease

Fat rat enables studies of debilitating vascular disease

Published in Obesity and Diabetes Week, October 24th, 2005

A mutant rat that mimics a 400-pound human is helping scientists understand early vascular changes that make walking painful for more than 2 million Americans.

"Everybody knows that obesity eventually causes diabetes and that when you have complications of the disease, you may even die," says Dr. David W. Stepp, cardiovascular researcher in the Medical College of Georgia Vascular Biology Center.

"What is underappreciated...is that there are vascular changes and cardiovascular effects of obesity well before you become diabetic."

The Obese Zucker rat model shares the symptoms of obesity with a growing number of Americans. "For...

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Source: Obesity and Diabetes Week (2005-10-24)

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