Diabetes Pathogenesis
AICAR and hyperosmotic stress increase insulin-stimulated glucose transport
Published in Obesity and Diabetes Week, October 31st, 2005
According to a study from the United States, "Sensitivity of glucose transport to stimulation by insulin has been shown to occur concomitant with activation of the AMP-activated protein kinase (AMFK) in skeletal muscle, suggesting a role of AMPK in regulation of insulin action. The purpose of the present study was to evaluate a possible role of AMPK in potentiation of insulin action in muscle cells. The experimental model involved insulin-responsive C2C12 myotubes that exhibit a two-fold increase in glucose transport in the presence of...
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