Diabetes Therapy
Adipose overexpression of GLUT4 reverses diabetes in mice lacking muscle GLUT4
Published in Obesity and Diabetes Week, October 31st, 2005
"Adipose tissue plays an important role in glucose homeostasis and affects insulin sensitivity in other tissues. In obesity and type 2 diabetes, glucose transporter 4 (GLUT4) is downregulated in adipose tissue, and glucose transport is also impaired in muscle. To determine whether overexpression of GLUT4 selectively in adipose tissue could prevent insulin resistance when glucose transport is impaired in muscle, we bred muscle GLUT4 knockout (MG4KO) mice to mice overexpressing GLUT4 in adipose tissue (AG4Tg)," researchers in the United States...
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