Published in Obesity and Diabetes Week, October 31st, 2005
"Elevation of free fatty acids (FFAs) by the infusion of triglyceride-heparin emulsion infusion (TG-Hep) causes insulin resistance (IR). We examined the effect of insulin sensitizer (rosiglitazone) on FFA-induced IR. Nine obese subjects underwent a 6-hour infusion of TG-Hep before and after 6 weeks of rosiglitazone (8 mg/d) treatment. Hyperinsulinemic euglycemic clamps were performed during 0-2 and 4-6 hours of TG-Hep," scientists in the United States report.
"After rosiglitazone for 6 weeks, fasting FFA concentration fell, but not significantly...
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