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Hypoglycemia

Novel ion-trap assay detects and measures eight sulfonylureas in plasma

Published in Obesity and Diabetes Week, November 7th, 2005

A novel ion-trap assay detects and measures eight sulfonylureas in plasma samples from patients with possible drug-induced hypoglycemia.

"Identification of sulfonylureas in blood may be useful in the evaluation of hypoglycemic crises of unknown origin," scientists in France explained.

In a recent study, G. Hoizey and coauthors at CHU de Reims sought to "develop a highly selective liquid chromatography-electrospray tandem mass spectrometry (MS-MS) method using an ion-trap detector for rapid screening, identification, and quantification of sulfonylureas in human plasma."

"After standard liquid-liquid extraction with glisoxepide as...

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